Analysis of cardiac dynamic global function
Leon Axel1, Mikael Kanski1, Amit Jhaveri1
1Department of Radiology and Department of Medicine, New York University Grossman School of Medicine, New York NY, USA.
JRSM Cardiovascular Disease
|June 19, 2026
Summary
This study introduces a systematic approach for analyzing dynamic global cardiac function using imaging data. It enables detailed assessment of cardiac volumes and function over the cardiac cycle, moving beyond traditional ejection fraction calculations.
Area of Science:
- Cardiovascular Imaging and Analysis
- Artificial Intelligence in Medicine
- Biomedical Engineering
Background:
- Conventional cardiac function analysis from images is limited to end-diastolic and end-systolic volumes and ejection fraction due to time-consuming segmentation.
- Advances in AI-assisted segmentation offer potential for detailed analysis of dynamic cardiac volume changes.
- Standardized methods for analyzing such dynamic data are currently lacking.
Purpose of the Study:
- To propose a systematic approach for analyzing dynamic global cardiac function from imaging data.
- To enable more detailed characterization of cardiac function beyond traditional metrics.
- To develop methods applicable to various imaging modalities, including cardiac magnetic resonance imaging (CMR).
Main Methods:
- Utilized cardiac magnetic resonance imaging (CMR) data from normal subjects and patients with heart failure with preserved ejection fraction.
- Analyzed ventricular volumes throughout the cardiac cycle.
- Calculated a set of dynamic global function variables, focusing on timing and rates of ventricular emptying and filling.
Main Results:
- A set of representative measures for timing and rates of ventricular emptying and filling was developed.
- These measures show promise as compact characterizations of dynamic global cardiac function.
- The approach was illustrated using CMR data, demonstrating its technical feasibility.
Conclusions:
- Efficient cardiac segmentation can significantly enhance the characterization of dynamic global cardiac function.
- The proposed measures of ventricular timing and rates offer a novel way to assess cardiac performance.
- This systematic approach has the potential to improve the understanding and management of cardiovascular diseases.
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