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Related Concept Videos

Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Cardiac Cycle01:29

Cardiac Cycle

The cardiac cycle refers to the sequence of events that occur in the heart from the beginning of one heartbeat to the next. It's characterized by alternating periods of contraction (systole) and relaxation (diastole) of the heart muscles.
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
Cardiac Action Potential01:30

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...

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Related Experiment Video

Updated: Jun 20, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Analysis of cardiac dynamic global function.

Leon Axel1, Mikael Kanski1, Amit Jhaveri1

  • 1Department of Radiology and Department of Medicine, New York University Grossman School of Medicine, New York NY, USA.

JRSM Cardiovascular Disease
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a systematic approach for analyzing dynamic global cardiac function using imaging data. It enables detailed assessment of cardiac volumes and function over the cardiac cycle, moving beyond traditional ejection fraction calculations.

Keywords:
CMRDynamic cardiac functioncardiac function analysiscardiac magnetic resonancedynamic global functionglobal cardiac functionmagnetic resonance imagingventricles

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Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis
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Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis

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Related Experiment Videos

Last Updated: Jun 20, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis
08:05

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis

Published on: May 19, 2021

Area of Science:

  • Cardiovascular Imaging and Analysis
  • Artificial Intelligence in Medicine
  • Biomedical Engineering

Background:

  • Conventional cardiac function analysis from images is limited to end-diastolic and end-systolic volumes and ejection fraction due to time-consuming segmentation.
  • Advances in AI-assisted segmentation offer potential for detailed analysis of dynamic cardiac volume changes.
  • Standardized methods for analyzing such dynamic data are currently lacking.

Purpose of the Study:

  • To propose a systematic approach for analyzing dynamic global cardiac function from imaging data.
  • To enable more detailed characterization of cardiac function beyond traditional metrics.
  • To develop methods applicable to various imaging modalities, including cardiac magnetic resonance imaging (CMR).

Main Methods:

  • Utilized cardiac magnetic resonance imaging (CMR) data from normal subjects and patients with heart failure with preserved ejection fraction.
  • Analyzed ventricular volumes throughout the cardiac cycle.
  • Calculated a set of dynamic global function variables, focusing on timing and rates of ventricular emptying and filling.

Main Results:

  • A set of representative measures for timing and rates of ventricular emptying and filling was developed.
  • These measures show promise as compact characterizations of dynamic global cardiac function.
  • The approach was illustrated using CMR data, demonstrating its technical feasibility.

Conclusions:

  • Efficient cardiac segmentation can significantly enhance the characterization of dynamic global cardiac function.
  • The proposed measures of ventricular timing and rates offer a novel way to assess cardiac performance.
  • This systematic approach has the potential to improve the understanding and management of cardiovascular diseases.