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Updated: Jun 20, 2026
10:41
A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)
Published on: April 30, 2020
Closing gaps through innovation in the tuberculosis pathology value chain
Anura David1, Lesley Scott1, Pedro da Silva2
1Wits Diagnostics Innovation Hub, Health Sciences Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Summary
Tuberculosis diagnosis faces critical gaps, with millions undiagnosed annually. Innovations in diagnostic methods and improved value chain processes are essential for timely detection and treatment of this infectious disease.
Area of Science:
- Global Health
- Infectious Diseases
- Medical Diagnostics
Background:
- Tuberculosis (TB) is a leading global infectious cause of death, with significant diagnostic gaps hindering control efforts.
- In 2024, millions of TB cases remain undiagnosed, highlighting systemic weaknesses in the diagnostic pathway.
- The TB diagnostic value chain encompasses patient identification, specimen handling, testing, reporting, and treatment linkage.
Purpose of the Study:
- To review challenges and opportunities within the TB diagnostic value chain.
- To focus on diagnostic bottlenecks and innovative solutions for improved accessibility and efficiency.
- To promote patient-centered care through enhanced diagnostic strategies.
Main Methods:
- Review of current TB diagnostic practices and value chain processes.
- Analysis of challenges in specimen collection, laboratory logistics, and result reporting.
- Exploration of novel diagnostic specimens and technologies, including molecular tests and point-of-care solutions.
Main Results:
- Sputum-based diagnostics pose challenges for certain populations; alternative specimens show promise but need validation.
- Laboratory and logistical constraints lead to diagnostic delays and patient attrition.
- Molecular diagnostics and digital tools offer improvements but face decentralization barriers.
Conclusions:
- Strengthening the TB diagnostic value chain requires investment in innovative technologies and infrastructure.
- Decentralized, near point-of-care diagnostics are crucial for reducing gaps and improving access to care.
- Coordinated efforts and policy frameworks are needed for equitable and timely TB diagnosis and treatment, especially in high-burden regions.
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