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  1. Home
  3. Electrical Stimulation And Stem Cell Subdural Implantation Decrease Microglia Reactivity After Spinal Cord Injury.
  1. Home
  3. Electrical Stimulation And Stem Cell Subdural Implantation Decrease Microglia Reactivity After Spinal Cord Injury.

Related Experiment Video

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury
10:56

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

Electrical stimulation and stem cell subdural implantation decrease microglia reactivity after spinal cord injury.

Loris Mannino1,2, Paolo Marracino1,3, Fernando Gisbert Roca1,4

  • 1RISEUP Consortium, Italy.

Materials Today. Bio
|June 19, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

This study introduces an Electro Pulsed Biohybrid (EPB) device for spinal cord injury (SCI) treatment, combining electrical stimulation (ES) and stem cells to improve recovery and reduce inflammation.

Keywords:
Bio-hybrid approachDirect currentElectrical stimulationImmunomodulationMicro pulsesSpinal cord injuryStem cells

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Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
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09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Biomedical Engineering

Background:

  • Spinal cord injury (SCI) causes permanent deficits due to initial trauma and secondary damage.
  • Electrical stimulation (ES) and stem cell therapy show potential for axonal regeneration and neuronal plasticity.

Purpose of the Study:

  • To develop and evaluate a novel implantable Electro Pulsed Biohybrid (EPB) device for combined ES and stem cell delivery in SCI.
  • To assess the impact of the EPB device on motor function, sensory output, cell behavior, and tissue response post-SCI.

Main Methods:

  • Designed an implantable EPB device for subdural delivery of human mesenchymal stem cells (hMSC) and induced neural stem cells (iNSC) with wired/wireless ES control.
  • Evaluated locomotion, sensory function, cell migration, neuroinflammation (microglia), gliosis, fibrosis, and neuronal survival.

Main Results:

  • Microsecond pulsed electric fields (μsPEFs) and continuous current enhanced hMSC migration and engraftment, reducing reactive microglia.
  • ES did not worsen gliosis, fibrosis, or neuropathic pain; stimulated animals showed improved running performance.
  • Both wired and wireless ES configurations yielded consistent positive outcomes.

Conclusions:

  • The EPB device's ES sequence modulated the early immune response, mitigating secondary damage.
  • The device facilitated implanted hMSC migration, offering a platform for combined cell therapy and ES in SCI treatment.