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Related Experiment Video

Updated: Jun 20, 2026

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

Electrical stimulation and stem cell subdural implantation decrease microglia reactivity after spinal cord injury.

Loris Mannino^1,2, Paolo Marracino^1,3, Fernando Gisbert Roca^1,4

¹RISEUP Consortium, Italy.

Materials Today. Bio

|June 19, 2026

Summary

This summary is machine-generated.

This study introduces an Electro Pulsed Biohybrid (EPB) device for spinal cord injury (SCI) treatment, combining electrical stimulation (ES) and stem cells to improve recovery and reduce inflammation.

Keywords:

Bio-hybrid approach Direct current Electrical stimulation Immunomodulation Micro pulses Spinal cord injury Stem cells

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Published on: December 17, 2014

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Area of Science:

Regenerative Medicine
Neuroscience
Biomedical Engineering

Background:

Spinal cord injury (SCI) causes permanent deficits due to initial trauma and secondary damage.
Electrical stimulation (ES) and stem cell therapy show potential for axonal regeneration and neuronal plasticity.

Purpose of the Study:

To develop and evaluate a novel implantable Electro Pulsed Biohybrid (EPB) device for combined ES and stem cell delivery in SCI.
To assess the impact of the EPB device on motor function, sensory output, cell behavior, and tissue response post-SCI.

Main Methods:

Designed an implantable EPB device for subdural delivery of human mesenchymal stem cells (hMSC) and induced neural stem cells (iNSC) with wired/wireless ES control.
Evaluated locomotion, sensory function, cell migration, neuroinflammation (microglia), gliosis, fibrosis, and neuronal survival.

Main Results:

Microsecond pulsed electric fields (μsPEFs) and continuous current enhanced hMSC migration and engraftment, reducing reactive microglia.
ES did not worsen gliosis, fibrosis, or neuropathic pain; stimulated animals showed improved running performance.
Both wired and wireless ES configurations yielded consistent positive outcomes.

Conclusions:

The EPB device's ES sequence modulated the early immune response, mitigating secondary damage.
The device facilitated implanted hMSC migration, offering a platform for combined cell therapy and ES in SCI treatment.