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Validity and Reliability of the CVI Range for Clinical Research: Baseline and One-Year Results

Melinda Y Chang1,2, Mark W Reid1, Christine Roman-Lantzy3

  • 1Division of Ophthalmology, The Vision Center at the Children's Hospital Los Angeles, Los Angeles, California.

Ophthalmology Science
|June 19, 2026
PubMed

Insights

The CVI Range-CR is a reliable and valid functional vision assessment for children with cerebral/cortical visual impairment (CVI). It shows high consistency and reliability, supporting its use in clinical trials for CVI.

Area of Science:

  • Ophthalmology
  • Pediatric Neurology
  • Developmental Pediatrics

Background:

  • Cerebral/cortical visual impairment (CVI) is a primary cause of vision impairment in children, affecting both visual function and daily activities.
  • Functional vision assessment is crucial for understanding and managing CVI's impact on a child's life.

Purpose of the Study:

  • To evaluate the psychometric properties, reliability, and validity of the CVI Range for Clinical Research (CVI Range-CR).
  • To establish the CVI Range-CR as a robust tool for CVI clinical trials.

Main Methods:

  • A prospective, longitudinal cohort study involving 40 children with CVI.
  • CVI Range-CR assessments were conducted at baseline and 1-year follow-up, with recordings analyzed by remote graders.
  • Interrater and intrarater reliability were assessed using intraclass correlation coefficients (ICC), and validity was evaluated against the 6-level visual behavior scale (VBS).

Main Results:

  • The CVI Range-CR demonstrated high internal consistency (McDonald's ω = 0.96) and excellent intrarater reliability (ICC = 0.88-0.98).
  • Good-to-excellent interrater reliability (ICC = 0.74-0.88) and strong correlation with VBS scores (Spearman's ⍴ = 0.76-0.86) were observed.
  • The assessment was sensitive to change, showing significant improvements in functional vision over one year.

Conclusions:

  • The CVI Range-CR is a reliable and valid measure for assessing functional vision in children with CVI.
  • Longitudinal studies should utilize consistent graders, potentially through remote grading via a centralized reading center, to maximize reliability.
Abstract

Keywords:
CVI rangeCerebral visual impairmentCortical visual impairmentFunctional vision assessment

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