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Post-translational modifications as a regulatory code for tau function in health and disease

Abigail J Nordbeck1,2, Bhirisha Sharma1,2, Charles A Garcia1

  • 1Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Tempe, AZ, United States.

Frontiers in Dementia
|June 19, 2026
PubMed
Summary

Tau protein modifications (PTMs) normally regulate neuronal function but become disrupted in tauopathies. Understanding these PTM networks is key to developing therapies for neurodegenerative diseases like Alzheimer's.

Keywords:
Alzheimer’s diseaseacetylationphosphorylationpost-translational modificationtauubiquitination

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