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Updated: Jun 20, 2026

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
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Published on: April 21, 2022

Should we routinely perform sperm DNA fragmentation testing in fertility clinics?

Srisailesh Vitthala1,2, Tarek El-Toukhy3, Abha Maheshwari4

  • 1MMC IVF Dubai, Dubai Healthcare City, Dubai, United Arab Emirates.

Human Reproduction Open
|June 19, 2026
PubMed
Summary

Sperm DNA fragmentation (SDF) testing is increasingly used in fertility evaluations but lacks sufficient evidence for routine screening or diagnostic use. Its application should be selective, avoiding overdiagnosis and unnecessary interventions.

Keywords:
diagnostic accuracymale infertilityprognostic testingreproductive outcomesscreening testssemen analysissperm DNA fragmentation

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