Related Experiment Video

Updated: Jun 20, 2026

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position
11:20

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

Published on: April 1, 2022

Long-term Outcomes of Pulmonary Valve Replacement in Infancy: Time for a Reassessment?

Almontasser Bella Kassier1, Abdelrahman Masri2, Hasan Iqfat3

  • 1Department of Cardiovascular Pediatric Surgery, Arkansas Children's Hospital, Little Rock, AR, USA.

Progress in Pediatric Cardiology
|June 19, 2026
PubMed

Insights

Pulmonary valve replacement in infants shows variable durability, often requiring reoperation due to growth and prosthetic limits. Alternative strategies like partial heart transplantation may improve outcomes for congenital heart disease patients.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Surgery
  • Congenital Heart Disease Research

Background:

  • Congenital heart disease (CHD) significantly impacts pediatric morbidity and mortality.
  • Pulmonary valve (PV) defects are common in children, necessitating surgical intervention like pulmonary valve replacement (PVR).
  • Limited data exists on the long-term efficacy of PVR in neonates and infants, especially considering somatic growth.

Purpose of the Study:

  • To assess the long-term outcomes and durability of pulmonary valve replacement (PVR) in neonates and infants.
  • To identify factors influencing the need for reoperation after PVR in this young population.

Main Methods:

  • A retrospective analysis of 62 neonates and infants undergoing PVR across 22 centers over 25 years.
  • Evaluation of surgical results, long-term follow-up data, and reoperation rates.
  • Complete outcome data was available for 22 patients.

Main Results:

  • Pulmonary valve replacement (PVR) demonstrated variable long-term durability in neonates and infants.
  • A significant number of patients required reoperation during the follow-up period.
  • Somatic growth and limitations of prosthetic valves were identified as contributing factors to reoperation.

Conclusions:

  • Current strategies for pulmonary valve replacement (PVR) in neonates and infants require reassessment.
  • Alternative treatments, such as partial heart transplantation, warrant further investigation for improved long-term results.
  • Optimizing PVR outcomes necessitates addressing challenges posed by patient growth and prosthetic limitations.
Abstract

Keywords:
Congenital heart DiseasesPartial heart transplantPediatricsPulmonary valve replacement

More Related Videos

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

Related Concept Videos

Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.
Mitral Stenosis IV: Nursing Management01:27

Mitral Stenosis IV: Nursing Management

A comprehensive nursing assessment is essential for patients with valvular heart disease, which involves any dysfunction of the heart valves that could impact blood flow and overall heart function.Subjective Data Collection:Chief Complaint and Present Illness: Start with the patient's primary concerns, focusing on the onset, duration, and progression of cardiac symptoms such as dyspnea, fatigue, chest pain, and palpitations.Past Medical History: Collect detailed information on any previous...
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...