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Related Concept Videos

Partial Differential Equations01:21

Partial Differential Equations

A stone dropped into a still pond generates waves that propagate outward in circular patterns, creating a dynamic surface whose elevation depends on both position and time. At any given location, the water level oscillates as the wave passes, while at any fixed moment, the surface exhibits smooth, curved structures extending across space. This dual dependence requires a mathematical description that accounts for variation in multiple variables simultaneously.At a fixed point on the water...
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Curves defined implicitly, where variables cannot be separated algebraically, require specialized techniques for analysis. The conchoid of Nicomedes exemplifies such a case. Its equation links x and y in a way that prevents isolation of one variable, making implicit differentiation essential to determine the slope and behavior at any point on the curve.The implicit form of the conchoid can be expressed as:To differentiate this equation, y is treated as a function of x, and the chain rule is...
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When analyzing the motion of falling objects, it is essential to consider not only the force of gravity but also the opposing force of air resistance. A practical example involves releasing a heavy test weight during a safety check on a ship. As the weight falls from rest, gravity accelerates it downward while air resistance exerts an upward force that increases with velocity. This dynamic interplay of forces is well described by differential equations, which provide a mathematical framework...
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Kinematic Equations: Problem Solving

When analyzing one-dimensional motion with constant acceleration, the problem-solving strategy involves identifying the known quantities and choosing the appropriate kinematic equations to solve for the unknowns. Either one or two kinematic equations are needed to solve for the unknowns, depending on the known and unknown quantities. Generally, the number of equations required is the same as the number of unknown quantities in the given example. Two-body pursuit problems always require two...
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A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
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Physics-informed differentiable solvers for learning parametric solution manifolds in heterogeneous physical systems.

Milad Panahi1, Giovanni Michele Porta1, Monica Riva1

  • 1Dipartimento di Ingegneria Civile e Ambientale, Politecnico di Milano, Piazza L. da Vinci 32, Milano 20133, Italy.

PNAS Nexus
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a new physics-informed neural network method to efficiently model complex systems with uncertain properties. It enables accurate simulations without costly retraining for each new parameter instance.

Keywords:
Darcy flowdifferentiable physicsparameterized PDEsphysics-informed neural networksuncertainty quantification

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Area of Science:

  • Computational fluid dynamics
  • Machine learning in geoscience
  • Partial differential equations

Background:

  • Parametric uncertainty quantification is crucial for modeling heterogeneous systems.
  • Spatial heterogeneity in system properties presents significant modeling challenges.
  • Existing methods often require extensive retraining for new parameter instances.

Purpose of the Study:

  • To develop a novel physics-informed neural network (PINN) framework for efficient parametric uncertainty quantification.
  • To reformulate PINNs as differentiable solvers capable of learning continuous solution manifolds.
  • To enable single-run training for steady-state Darcy flow problems with heterogeneous parameters.

Main Methods:

  • Reformulating a physics-informed neural network as a differentiable solver.
  • Utilizing a single training run to learn the continuous solution manifold.
  • Employing autoencoders for low-dimensional latent encoding of hydraulic conductivity fields.
  • Integrating a differentiable decoder into the physics-informed loss function for on-the-fly field reconstruction.

Main Results:

  • Accurate and mass-conserving solutions for steady-state Darcy flow were achieved.
  • Efficient uncertainty quantification was demonstrated for heterogeneous systems.
  • The framework circumvents the need for repeated retraining for different parameter instances.
  • Successful reconstruction of complex conductivity fields was enabled through the integrated decoder.

Conclusions:

  • The proposed differentiable PINN solver offers a general methodology for physics-constrained data-driven modeling of heterogeneous systems.
  • This approach significantly enhances the efficiency of uncertainty quantification in complex subsurface flow simulations.
  • The integration of autoencoders and differentiable decoders provides a powerful tool for handling spatially varying parameters.