Resolved hyperthyroidism before IVF is not associated with improved cumulative live birth rates: a retrospective
Huizi Jin1, Jiejun Luo1, Menglu Wu1
1Department of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Frontiers in Endocrinology
|June 19, 2026
Summary
Women with active hyperthyroidism (AH) experience poorer in vitro fertilization (IVF) outcomes. However, resolved hyperthyroidism (RH) did not significantly impact IVF success rates compared to controls, suggesting potential recovery of ovarian function.
Area of Science:
- Reproductive Endocrinology
- In Vitro Fertilization
- Thyroid Disorders
Background:
- Hyperthyroidism negatively affects female reproductive health, but its precise impact on in vitro fertilization (IVF) outcomes remains debated.
- It is unclear if ovarian function fully recovers after achieving a euthyroid state.
Purpose of the Study:
- To compare IVF outcomes in women with active hyperthyroidism (AH), resolved hyperthyroidism (RH), and normal controls (NC).
- To investigate the relationship between hyperthyroidism duration and cumulative live birth rates (CLBR).
Main Methods:
- Retrospective analysis of 17,621 first oocyte retrieval cycles (January 2014-September 2022).
- Patients categorized into AH, RH, and NC groups based on thyroid function tests and medical history.
- Cumulative live birth rate (CLBR) per aspiration cycle was the primary outcome, analyzed using multivariable logistic regression and inverse probability weighting (IPW).
Main Results:
- Active hyperthyroidism (AH) was associated with significantly lower fresh cycle live birth rates (LBR) compared to normal controls (NC).
- Adjusted models showed lower LBR and CLBR in the AH group versus NC, with no significant difference between AH and RH groups.
- Longer duration of hyperthyroidism correlated with a reduced CLBR in patients with active or resolved hyperthyroidism.
Conclusions:
- Preconception hyperthyroidism is linked to diminished IVF success.
- Prolonged hyperthyroidism duration is a significant negative predictor of cumulative live birth rates in IVF patients.
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