Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Renewal of Skin Epidermal Stem Cells

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Whole Body Regeneration

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The impact of the six pillars of lifestyle medicine on the biology of skin aging.

Frontiers in aging·2026

Same author

Older adults with advanced chronic illness and emergency department care: the hermeneutic stories of Bill, Edie and Nicole.

BMC geriatrics·2026

Same author

Factors Associated with Antiretroviral Therapy Re-Engagement Among Men Who Have Sex with Men in South Africa: A Multi-District Analysis.

Viruses·2026

Same author

Biological Photoprotection: A Review of its Mechanisms, Evidence, and Clinical Implications.

Dermatology and therapy·2026

Same author

The Association Between HIV Testing Modality and Antiretroviral Therapy Initiation Among Men Who Have Sex with Men in Selected Provinces of South Africa.

International journal of environmental research and public health·2026

Same author

Effects of solar-simulated (UVB plus UVA) radiation on the skin microbiome: An exploratory study.

Photochemistry and photobiology·2026

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Homeodynamic Rejuvenation: an adaptive framework for resetting skin aging.

Anthony Brown¹, Carla Simonetto¹, Carlos López-Otín^2,3

¹Innovation and Development, ISDIN, Barcelona, Spain.

Frontiers in Aging

|June 19, 2026

Summary

Homeodynamic Rejuvenation focuses on restoring the skin's ability to manage stress and recover, rather than reversing aging signs. This approach enhances skin resilience by reactivating key cellular repair and recovery systems.

Keywords:

Homeodynamic Rejuvenation adaptive capacity exposome extracellular matrix homeodynamic plasticity homeodynamics photoaging skin aging

Related Experiment Videos

Last Updated: Jun 20, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Area of Science:

Dermatology
Integrative Biology
Skin Physiology

Background:

Skin aging involves molecular damage and reduced ability to adapt to environmental stress.
Current aging models don't fully capture the dynamic nature of skin adaptation.
Homeodynamic Rejuvenation offers a new framework for understanding and addressing skin aging.

Purpose of the Study:

Introduce Homeodynamic Rejuvenation as a novel concept for skin vitality.
Define homeodynamic plasticity as the skin's capacity to maintain function under stress.
Integrate homeodynamics with exposome biology to target cellular repair and recovery.

Main Methods:

Focus on five core biological processes: intracellular quality control, regenerative competence, metabolic resilience, cellular integrity, and structural integrity.
Link these processes to functional decline and skin aging, including dermatoporosis.
Propose evaluation through dynamic perturbation-recovery kinetics to measure stress response and recovery.

Main Results:

Homeodynamic plasticity underpins the skin's ability to sustain function under stress.
Failure in core biological processes leads to progressive functional decline and aging.
Dynamic perturbation-recovery kinetics can quantify skin resilience.

Conclusions:

Homeodynamic Rejuvenation aims to restore functional competence and biological vitality.
This framework targets the reactivation of cellular systems for stress sensing, repair, and recovery.
It provides a structured, translational approach to quantifying and restoring skin resilience.