Synchronous primary HPV-associated squamous cell carcinomas of the cervix and fallopian tube: a case report

Cervical squamous cell carcinoma has been proven to be associated with human papillomavirus(HPV) infection, while the etiology of fallopian tube squamous cell carcinoma remains unclear and there are few literature reports. Clinically, concurrent cases of the two malignancies are even more rare. A female patient presented to our hospital with irregular vaginal bleeding. She underwent hysteroscopic surgery, and the postoperative pathology indicated cervical cancer. She subsequently received laparoscopic surgery, and postoperative pathology unexpectedly confirmed squamous cell carcinoma of the fallopian tube. We speculate that this represents a case of HPV-associated double primary squamous cell carcinomas. At present, the patient's general condition is stable after systematic treatment. This case reminds us to further understand the relationship between HPV infection and gynecological malignancies, as well as the benefits of rational application of opportunistic salpingectomy (OS), and we should strive for early diagnosis and treatment of tumors.