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Systemic inflammatory index correlates with cerebral small vessel disease in Parkinson's disease

Yongqing Cheng1,2, Haiping Tang3, Shuangfei You1

  • 1Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.

Frontiers in Aging Neuroscience
|June 19, 2026
PubMed
Abstract

Insights

Elevated systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) are linked to increased cerebral small vessel disease (CSVD) severity in Parkinson

Area of Science:

  • Neurology
  • Inflammation Research
  • Biomarkers

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder.
  • Cerebral small vessel disease (CSVD) is common in PD patients.
  • Systemic inflammatory indices may reflect disease processes in PD.

Purpose of the Study:

  • To investigate the association between SII and SIRI and CSVD severity in PD patients.
  • To determine if SII and SIRI can predict moderate-severe CSVD in PD.

Main Methods:

  • 167 PD patients with MRI data were analyzed.
  • CSVD severity was assessed using total and modified CSVD burden scores.
  • Logistic and ROC analyses evaluated the association of SII and SIRI with CSVD severity.

Main Results:

  • Higher SII and SIRI levels were observed in patients with moderate-severe CSVD.
  • SII and SIRI showed significant associations with moderate-severe CSVD after adjusting for covariates.
  • Elevated tertiles of SII and SIRI were independently associated with increased CSVD burden.

Conclusions:

  • Elevated SII and SIRI are independently associated with more severe CSVD in PD patients.
  • These inflammatory indices may serve as potential biomarkers for CSVD severity in PD.
Keywords:
Parkinson’s diseasecerebral small vessel diseaseinflammatory markersystemic immune inflammation indexsystemic inflammation response index

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