Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pulmonary Edema II: Pathophysiology

Pulmonary Edema II: Pathophysiology

Pulmonary edema is the accumulation of fluid in the interstitial and alveolar spaces of the lungs, impairing gas exchange and oxygen delivery. It may be cardiogenic or noncardiogenic, but both reduce oxygenation and lung compliance.Cardiogenic Pulmonary EdemaCardiogenic edema results from increased hydrostatic pressure in pulmonary capillaries, usually due to left ventricular dysfunction from myocardial infarction, heart failure, or valvular disease. Ineffective cardiac pumping causes blood to...

Epistaxis

Epistaxis

Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...

Suctioning the Nasopharyngeal Airway

Suctioning the Nasopharyngeal Airway

Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required

Pneumothorax II: Pathophysiology

Pneumothorax II: Pathophysiology

Pneumothorax means the presence of air in the pleural space — the thin potential gap between the visceral and parietal pleura. This condition disrupts the normal pressure balance that keeps the lungs inflated, leading to partial or complete collapse of the affected lung.Normal physiologyUnder normal conditions, the pleural space maintains a slightly negative intrapleural pressure, which keeps the lungs expanded against the chest wall. This negative pressure creates a delicate balance between...

Pneumothorax-II

Pneumothorax-II

Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:

Pulmonary Cycle: Exhalation

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Acceptability of Self-sampling in Human Papillomavirus Deoxyribonucleic acid based Cervical Screening in Nepal: A Mixed-Methods Study.

Kathmandu University medical journal (KUMJ)·2026

Same author

Superficial Cervical Plexus Block During Internal Jugular Vein Cannulation for Pain Relief in Awake Patient.

Kathmandu University medical journal (KUMJ)·2026

Same author

En Bloc Versus Conventional Resection of Primary Bladder Tumor.

Kathmandu University medical journal (KUMJ)·2026

Same author

Evaluating the Impact and Feasibility of Case-Based Learning in Enhancing Histopathology Education among Dental Students.

Kathmandu University medical journal (KUMJ)·2026

Same author

Dietary Salt Intake in a Suburban Nepali Community: A Cross-sectional Study Using 24-Hour Urinary Sodium.

Kathmandu University medical journal (KUMJ)·2026

Same author

Epidemiology of Critically Ill Patients in Intensive Care Units in Dhulikhel Hospital, Nepal: a retrospective observational study.

Kathmandu University medical journal (KUMJ)·2026

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation

Published on: June 20, 2018

Negative Pressure Pulmonary Edema Following Septorhinoplasty.

B R Shrestha¹, A Bajracharya¹, A Shrestha¹

¹Department of Anesthesiology, Aarus Lifestyle Hospital, Kupondole Height, Lalitpur, Nepal.

Kathmandu University Medical Journal (KUMJ)

|June 19, 2026

Summary

Negative pressure pulmonary edema (NPPE) is a rare but serious complication after general anesthesia. Prompt recognition and treatment are crucial for managing this condition and preventing severe outcomes.

Related Experiment Videos

Last Updated: Jun 20, 2026

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation

Published on: June 20, 2018

Area of Science:

Anesthesiology
Pulmonology
Critical Care Medicine

Background:

Negative pressure pulmonary edema (NPPE) is a potentially fatal condition.
It occurs after general anesthesia due to strenuous inspiratory efforts against an obstructed airway.
This leads to negative intrathoracic pressure, causing pulmonary edema, hypoxia, and acidosis.

Purpose of the Study:

To report a case of NPPE following septorhinoplasty under general anesthesia.
To discuss the management approach, treatment considerations, and outcomes for NPPE.
To highlight the importance of early recognition and prompt treatment.

Main Methods:

Case report of a 36-year-old female who developed NPPE post-general anesthesia.
Review of the patient's clinical presentation, diagnostic findings, and treatment course.
Discussion of the pathophysiology and risk factors associated with NPPE.

Main Results:

The patient developed NPPE after septorhinoplasty.
Management involved supportive care and addressing the underlying airway obstruction.
The patient's outcome was favorable following prompt intervention.

Conclusions:

NPPE is a significant risk following general anesthesia, particularly with airway obstruction.
Careful patient management, early detection, and timely treatment are essential for favorable outcomes.
This case underscores the importance of vigilance for NPPE in at-risk patients.