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Published on: May 13, 2020
PCN-224-Pt nanozyme for dual-mode detection of acetylcholinesterase viaLMB-PEG
Weiyi Bai1, Ling Teng1, Xingzhi Yu1
1Department of Laboratory Medicine, Precision Medicine Translational Research Center, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. weihuaz@scu.edu.cn.
Abstract:
Alzheimer's disease (AD) is closely associated with cholinergic dysfunction, with acetylcholinesterase (AChE) as a key biomarker. Here, a dual-mode colorimetric/fluorescent platform based on PCN-224-Pt nanozyme and LMB-PEG is developed, enabling rapid, sensitive AChE detection with broad linear ranges, low limits, and improved selectivity, stability, and anti-interference for neurodegenerative disease diagnosis.
