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Updated: Jun 20, 2026

Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
Published on: April 3, 2026
Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical
Xiaoqian Zhu1, Liwei Hong1, Weihan Chen1
1Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 515000, P.R. China.
Abstract:
Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies worldwide, characterized by persistently high and increasing rates of incidence, recurrence and mortality, thereby posing a considerable global public health challenge. Within the complex molecular network driving the malignant progression of HNSCC, Dickkopf‑1 (DKK1), a classical secreted antagonist of the Wnt signaling pathway, has garnered considerable attention due to its pleiotropic roles in tumor initiation, progression and therapeutic resistance. The expression of DKK1 is regulated by a sophisticated network involving both canonical and non‑canonical Wnt pathways, and it exhibits high spatiotemporal specificity and context dependency. The present narrative review discusses the regulatory mechanisms underlying DKK1 expression, its prognostic significance in HNSCC, pro‑tumorigenic molecular mechanisms, immunomodulatory functions and its clinical translational potential as a biomarker and therapeutic target. The present review aims to provide novel insights into the pathogenesis of HNSCC and establish a theoretical foundation for advancing DKK1‑based precision diagnostics and therapeutic strategies.
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