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Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
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General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
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Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

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Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

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Related Experiment Video

Updated: Jun 20, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

Intraoperative Noise Isolation as an Opioid-Sparing Strategy: A Systematic Review and Meta-analysis.

Gang Deng1, Mengping Tian1, Fang Wang2

  • 1School of Basic Medical Sciences & School of Nursing, Chengdu University, Chengdu, Sichuan, China; Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.

Journal of Perianesthesia Nursing : Official Journal of the American Society of Perianesthesia Nurses
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

Intraoperative noise isolation using earmuffs reduces postoperative pain and opioid use. This safe strategy enhances recovery quality, especially in moderate-pain surgeries like laparoscopy.

Keywords:
ear-protective devicesnoiseopioid-sparingpostoperative painquality of recovery

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Last Updated: Jun 20, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

Non-Intubated Video-Assisted Thoracoscopic Surgery
05:39

Non-Intubated Video-Assisted Thoracoscopic Surgery

Published on: May 26, 2023

Area of Science:

  • Anesthesiology
  • Pain Management
  • Surgical Recovery

Background:

  • Postoperative pain and opioid consumption are significant concerns.
  • Minimizing intraoperative sensory stimuli may improve patient outcomes.

Purpose of the Study:

  • To assess the efficacy of intraoperative noise-isolating earmuffs.
  • To evaluate effects on postoperative pain, opioid use, and recovery quality.

Main Methods:

  • Systematic review and meta-analysis of 3 randomized controlled trials (296 patients).
  • Searched 9 databases up to December 2025.
  • Assessed risk of bias using Cochrane RoB 2.0 tool.

Main Results:

  • Noise isolation significantly reduced perioperative opioid consumption (MD = -4.73 MME) and PCIA boluses.
  • Improved recovery quality at 24 hours postoperatively (QoR-15 scores).
  • Lower resting pain scores in laparoscopic surgery, but not ESD, possibly due to floor effect.

Conclusions:

  • Intraoperative noise isolation is a safe, cost-effective, opioid-sparing strategy.
  • Enhances early quality of recovery with moderate-certainty evidence.
  • Benefits are context-dependent, with greater efficacy in moderate-pain procedures.