Related Experiment Video
Updated: Jun 20, 2026
Implantation Protocol of the Foldable Capsular Vitreous Body for Complex Vitreoretinal Surgery
Published on: April 14, 2026
Evaluation of retinochoroidal changes after implantable collamer lens implantation: insights from UWF-SS-OCTA and
Xuze Wang1, Jun Wang1, Dejuan Song1
1Eye Center of Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou, People's Republic of China.
Purpose:
To evaluate the long-term changes in retinochoroidal structure and perfusion status in highly myopic eyes following ICL V4c implantation, using ultra-widefield swept-source optical coherence tomography angiography (UWF-SS-OCTA) combined with a three-dimensional modelling algorithm.
Design:
Prospective cohort study.
Subjects:
Sixty-six highly myopic patients (132 eyes) underwent ICL V4c implantation surgery and completed one year of follow-up.
Methods:
Retinal and choroidal parameters, including retinal thickness (RT), capillary plexus density, foveal avascular zone (FAZ), retinal curvature, choroidal thickness (CT), and three-dimensional choroidal vascularity index (3D-CVI), were measured preoperatively and at multiple postoperative time points using UWF-SS-OCTA integrated with advanced 3D analytic techniques. Repeated measures mixed-effects models were applied to compare the pre- and postoperative parameters and test the correlations between parameters.
Results:
The surgical outcomes are satisfactory with a stable safety profile and no major complications. RT and retinal vascular density exhibited transient changes in one month postoperatively, and gradually recovered (p < 0.05). Choroidal parameters, including CT and 3D-CVI, demonstrated a progressive and sustained postoperative increase across the 1-year follow-up, with the most pronounced changes observed in the foveal and perifoveal zones (p < 0.001). Factors of surgical duration and axial length showed significant correlation to the retinochoroidal responses (p < 0.05).
Conclusion:
Our analysis based on UWF-SS-OCTA demonstrated that ICL implantation can cause the recoverable changes of retinal structure and perfusion status, and the sustained remodeling of choroidal vascular conditions one year postoperatively in high myopia.
Trial Registration Number:
ChiCTR2500108664, registered at the Chinese Medical Research Registry.
