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Updated: Jun 21, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Correlation between circ_0092576 and Arterial Stenosis Severity and Inflammatory Status in Patients with Coronary

Wenqin Dai1, Lingli Wang2, Yuan Li3

  • 1Department of Cardiology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430063, Hubei, China.

Folia Biologica
|June 19, 2026
PubMed

Insights

Circular RNA circ_0092576 shows promise as a biomarker for coronary heart disease (CHD). Higher levels predict increased CHD risk, severe stenosis, inflammation, and major adverse cardiac events (MACE).

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Coronary heart disease (CHD) poses a significant global health burden.
  • Identifying reliable biomarkers for CHD risk and prognosis is crucial for early intervention.
  • The role of circular RNAs (circRNAs) in cardiovascular diseases is an emerging area of research.

Purpose of the Study:

  • To evaluate the predictive value of circ_0092576 for CHD and major adverse cardiac events (MACE).
  • To investigate the association between circ_0092576 levels and coronary artery stenosis severity.
  • To explore the relationship between circ_0092576 and inflammatory markers in CHD patients.

Main Methods:

  • Quantitative real-time PCR (RT-qPCR) was used to measure plasma levels of circ_0092576, IL-1β, TNF-α, and IL-10.
  • Gensini score system assessed coronary artery stenosis severity.
  • Patient follow-up was conducted to record MACE occurrence.

Main Results:

  • circ_0092576 levels were significantly elevated in CHD patients compared to controls (AUC=0.885).
  • circ_0092576 positively correlated with Gensini scores, IL-1β, and TNF-α, and negatively with IL-10.
  • Higher circ_0092576 levels were associated with increased MACE risk and cumulative incidence.

Conclusions:

  • circ_0092576 is a potential biomarker for CHD risk and prognosis.
  • Elevated circ_0092576 levels indicate higher risk of CHD, more severe coronary artery stenosis, and increased inflammation.
  • circ_0092576 may serve as a predictor for adverse cardiac events in CHD patients.

Keywords:
CHDMACEcirc_0092576inflammation

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