Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Improving Translational Accuracy

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

Improving Translational Accuracy

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Loop extrusion by cohesin plays a role in enhancer-activated gene expression early in differentiation.

Nature communications·2026

Same author

MYB activity drives emergent enhancer activation and enhancer-promoter interactions in acute lymphoblastic leukemia.

Blood·2026

Same author

Deciphering <i>cis</i>-regulatory elements using REgulamentary.

Bioinformatics advances·2026

Same author

A functional overlap between actively transcribed genes and chromatin insulator elements.

The EMBO journal·2026

Same author

A high-resolution atlas of the brain predicts lineage and birth order underlying neuronal identity.

Cell genomics·2025

Same author

Navigating the Hepatic Immune Landscape With Fine Needle Aspiration of the Liver-An Emerging Technique.

Liver international : official journal of the International Association for the Study of the Liver·2025

Same journal

NanoporeDB: A Structural Resource Of Multimeric Protein Nanopores For Single-Molecule Sensing.

GigaScience·2026

Same journal

From the Brain Cell Atlas to Precision Neurology: A review of the application of AI-driven multi-omics in brain science.

GigaScience·2026

Same journal

Comparison of Deep Learning Approaches for Extreme Low-SNR Image Restoration.

GigaScience·2026

Same journal

ScopeViewer: A Browser-Based Solution for Visualizing Large Biological Images.

GigaScience·2026

Same journal

ClusterGraph: a new tool for visualisation and compression of multidimensional data.

GigaScience·2026

Same journal

MultiMS2: A curated multi-modal, multi-energy spectral library for metabolomics.

GigaScience·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

ChatMDV: Reducing Technical Barriers in Bioinformatics Analysis using Large Language Models.

Maria Kiourlappou¹, Peter Todd¹, Yaxuan Kong²

¹Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford.

|June 19, 2026

Summary

This summary is machine-generated.

ChatMDV simplifies complex biological data visualization using natural language commands. This tool enhances accessibility and reproducibility for researchers in genomics and spatial omics.

Keywords:

Bioinformatics Data Visualisation FAIR Principles Large Language Models Natural Language Interfaces

More Related Videos

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

Published on: December 6, 2024

Related Experiment Videos

Last Updated: Jun 21, 2026

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

Published on: December 6, 2024

Area of Science:

Bioinformatics
Computational Biology
Genomics

Background:

Advanced omics technologies generate complex biological data.
Existing visualization tools like Multi-Dimensional Viewer (MDV) require significant computational expertise.
Limited accessibility hinders widespread use of powerful data exploration platforms.

Purpose of the Study:

To develop a natural language interface for MDV to simplify biological data visualization.
To enhance accessibility and reproducibility in analyzing complex omics datasets.
To enable users to generate interactive visualizations and analyses via conversational commands.

Main Methods:

Integration of a natural language interface with the Multi-Dimensional Viewer (MDV).
Utilized a retrieval-augmented generation (RAG) pipeline and large language models (LLMs).
Translated natural language queries into executable Python code for reproducible analyses.

Main Results:

ChatMDV successfully generated high-quality, interactive visualizations from natural language queries.
Demonstrated capabilities across diverse datasets including single-cell RNA-sequencing (scRNA-seq) data.
Achieved high semantic success rates (79-97%) in data visualization tasks.

Conclusions:

ChatMDV bridges natural language processing and bioinformatics visualization, reducing technical barriers.
Enhances reproducibility and inclusivity in scientific inquiry.
Its modular and FAIR-compliant design supports scalable biological data analysis.