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Related Concept Videos

Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

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Updated: Jun 21, 2026

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition
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2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

Published on: December 26, 2016

Timing Matters: Denture Use for Cognitive Protection is Most Effective Before Major Tooth Loss.

Ruotong Zhang1, Xiaochen Liu2

  • 1College & Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, Hefei, 230032.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

Tooth loss accelerates cognitive decline in older adults. Early denture use significantly mitigates this risk, preserving cognitive function and highlighting the importance of timely dental interventions.

Keywords:
cognitive declinedentureslongitudinal studytooth losstrajectory analysis

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Published on: December 20, 2024

Area of Science:

  • Gerontology
  • Cognitive Neuroscience
  • Dental Public Health

Background:

  • Tooth loss is a recognized risk factor for cognitive decline.
  • Longitudinal data on the protective effects of dentures and optimal intervention timing are limited.
  • Understanding these associations is crucial for cognitive preservation strategies in aging populations.

Purpose of the Study:

  • To examine the relationship between tooth loss, denture use, and cognitive trajectories in older adults.
  • To investigate how changes in tooth status and denture use influence cognitive decline.
  • To determine the impact of intervention timing for dentures on cognitive health.

Main Methods:

  • A prospective cohort study of 2,188 community-dwelling older adults was conducted.
  • Group-based trajectory modeling (GBTM) identified distinct cognitive pathways.
  • Multinomial logistic regression analyzed associations between tooth loss, denture use, and cognitive trajectories.

Main Results:

  • Two cognitive trajectories were identified: maintained-high (57.4%) and low-declining (42.6%).
  • Significant associations were found between baseline tooth loss and progression to severe tooth loss with increased risk of the low-declining cognitive trajectory.
  • Denture use demonstrated a protective effect, reducing the risk of adverse cognitive trajectories, with greatest benefit observed when used early.

Conclusions:

  • Tooth loss is a significant risk factor for adverse cognitive trajectories in older adults.
  • Denture use mitigates cognitive decline risk, with effectiveness dependent on early intervention.
  • Timely prosthodontic intervention is a potential strategy for cognitive preservation.