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Isolation and Transcriptome Analysis of Plant Cell Types
08:53

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Published on: April 7, 2023

Single-nucleus transcriptomics resolves multiple fate dynamics between inflorescence meristem and primary stem.

Sebastián Moreno-Ramírez1, Martin O Lenz1,2, Elliot M Meyerowitz1,3

  • 1Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK.

Science Advances
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

This study maps the transcriptional journey of stem cells in flowering plant inflorescence meristems. It reveals gene expression dynamics driving differentiation into various plant organs.

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Area of Science:

  • Plant biology
  • Developmental biology
  • Genomics

Background:

  • The inflorescence meristem (IM) is a crucial stem cell niche in plants, generating aboveground organs.
  • Understanding cell differentiation dynamics within the IM is essential for plant development but remains largely unknown.

Purpose of the Study:

  • To characterize the transcriptional landscape of the IM using single-nucleus RNA sequencing.
  • To link shoot stem cells to early differentiation cell types and understand transcriptional dynamics.

Main Methods:

  • Single-nucleus RNA sequencing (snRNA-seq) was employed to profile the IM.
  • Trajectory inference analysis was used to model cell differentiation pathways.

Main Results:

  • snRNA-seq revealed transcriptional patterns, including early cortex patterning and the role of *GH3* genes in meristem activity.
  • Trajectory inference identified cell cycle dynamics (S-G2-M phases) and gene programs for differentiation into primordia, cortex, cambium, xylem, and phloem.

Conclusions:

  • This research elucidates cell fate transcriptional dynamics during shoot organ development.
  • The findings provide a comprehensive view of stem cell differentiation within the plant inflorescence meristem.