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Risk Factors for Postoperative Complications in Patients Reoperated for Persistent/Recurrent Differentiated Thyroid
Jinlan Shao1, Chunhua Zhang1, Xiaofan Zhu1
1Department of Head and Neck Surgery, Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Cancer Research Institute Cancer, Nanjing, Jiangsu, China.
The Journal of Surgical Research
|June 19, 2026
Summary
Reoperation for differentiated thyroid carcinoma (DTC) carries risks. Previous surgeries, extensive lymphadenectomy, and longer operative times increase postoperative complications, aiding early detection and prevention.
Area of Science:
- Head and Neck Surgery
- Endocrine Surgery
- Oncology
Background:
- Persistent/recurrent differentiated thyroid carcinoma (DTC) often requires reoperation.
- Identifying perioperative risk factors for complications is crucial for patient safety.
Purpose of the Study:
- To identify perioperative risk factors for postoperative complications in patients undergoing reoperation for persistent/recurrent DTC.
- To inform strategies for early detection and prevention of complications.
Main Methods:
- Retrospective study of 97 patients with persistent/recurrent DTC undergoing reoperation.
- Assessment of postoperative complications including hypoparathyroidism, lymphatic leakage, nerve injury, and bleeding.
- Multivariable logistic regression analysis to identify independent risk factors.
Main Results:
- Factors significantly associated with postoperative complications included: number of previous surgeries (OR=3.91), bilateral lateral cervical lymphadenectomy (OR=4.69), thoracic duct ligation (OR=4.01), parathyroid hormone levels at admission (OR=0.58), and operative time (OR=1.57).
- 38 out of 97 patients experienced at least one postoperative complication.
Conclusions:
- Perioperative factors such as prior surgical history and operative details are critical predictors of complications after DTC reoperation.
- These findings enable healthcare professionals to better anticipate, manage, and prevent complications, improving patient outcomes.
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