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Updated: Jun 21, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
Decoding nucleic acid modification regulatory networks: A key to cancer intervention and treatment
Qi Sun1, Yunxuan Shi2, Yadong Guo3
1Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
None:
Nucleic acid modification constitutes a pivotal regulatory mechanism in cancer, influencing the entire process of tumor development, diagnosis, treatment, and prognosis. This review delineates the role of diverse chemical modifications-including methylation, demethylation, N6-methyladenosine, and 5-methylcytosine-in governing genomic stability and cellular dysfunction across DNA, coding RNA, and non-coding RNA levels. The research paradigm of nucleic acid modification in cancer is transitioning from static modification maps to dynamic, interconnected modification networks. Moreover, the crosstalk between nucleic acid modifications and nucleic acid processing further intensifies epigenetic remodeling and oncogenic risk. Elucidating the fundamental mechanisms underlying these modifications will provide critical insights into their overarching significance in cancer initiation and maintenance, while offering promising diagnostic and therapeutic targets for precise targeted treatment of cancer at the nucleic acid level.
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