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Updated: Jun 21, 2026

Recombineering Homologous Recombination Constructs in Drosophila
Published on: July 13, 2013
Bridging paradoxes in recombination at NLR cluster: A structural genomics perspective
Gianluca Teano1, Alexandre Roudaut1, Ariane Gratias1
1Université Paris-Saclay, CNRS, INRAE, Université Evry, Institute of Plant Sciences Paris-Saclay (IPS2), 91190, Gif sur Yvette, France.
Abstract:
The paradox of recombination within NLR resistance gene clusters lies in the observation that these loci can exhibit either pronounced suppression or, conversely, unusually high rates of meiotic recombination, profoundly influencing allelic diversity and the evolutionary trajectory of plant immunity clusters. In recent years, progress in genome sequencing has provided novel insights into the breadth of structural variation at NLR clusters, shedding new light on these seemingly contradictory results. This review highlights recent technological advances that have enabled large-scale sequencing of complex NLR clusters, revealing previously hidden structural variation. We illustrate these findings with selected examples of NLR clusters from diverse plant species. Finally, we discuss the impact of structural variation on meiotic recombination within NLR clusters.
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