Bio-catalytic nanofibers with sonodynamic therapy for rapid sterilization and enhanced infected wound healing

Sonodynamic therapy (SDT) has been considered as a promising way to treat multidrug-resistant (MDR) bacterial infections. However, the efficiency of SDT is usually limited by rapid recombination of electron-hole pairs triggered by ultrasound in sonosensitizers. To address this problem, we designed a new wound dressing composing lithium iron phosphate (LFP)/MXene (vanadium carbide) heterojunction (HJ). The constructed HJ exhibits high-efficient ROS production, Fe²⁺ catalyzed ·OH generation while Fe³⁺ oxidized consumption of GSH in bacteria. Furthermore, LFP is slowly degraded into non-toxic species including Li⁺, Fe³⁺, and PO₄^3-, while MXene is released from the composite. In vitro evaluations demonstrate that the composite membrane exhibits superior antibacterial performance against both S. aureus and E. coli through irreversible bacterial membrane disruption. Furthermore, in a full-thickness infected wound model, the engineered dressing significantly accelerates wound closure by eliminating infection. This study presents a viable paradigm for designing high-performance heterojunction-based fibrous scaffolds for the clinical management of infected wounds.