Related Experiment Video

Updated: Jun 21, 2026

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
09:37

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

Published on: March 15, 2018

Nrf2 dynamically regulates RANKL-induced osteoclastogenesis and cathepsin K function.

Cesar A Speck-Hernandez1, Taíssa C de Souza Furtado2, Laisa Y de Souza3

  • 1Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil; Laboratory of Bone Biology, Department of Biomolecular Sciences, School of Pharmaceutical Sciences, Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

The Journal of Biological Chemistry
|June 19, 2026
PubMed
Summary

Nuclear factor erythroid 2-related factor 2 (Nrf2) is crucial for osteoclast function. It balances reactive oxygen species (ROS) and maintains lysosomal integrity, impacting bone resorption and Cathepsin K activity.

Keywords:
Lipid PeroxidationMitochondriaNrf2OsteoclastsOxidative StressROS

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