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Genetic variants associated with clinical characteristics and atopies in eosinophilic esophagitis.

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Updated: Jun 21, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Tissue remodeling in eosinophilic esophagitis.

Seema Aceves1, Mario C Manresa2, Evan S Dellon3

  • 1Division of Allergy and Immunology, University of California, San Diego and Rady Children's Hospital, San Diego, CA, United States.

The Journal of Allergy and Clinical Immunology
|June 19, 2026
PubMed
Summary

Eosinophilic esophagitis (EoE) is a chronic allergic disease causing esophageal dysfunction. Prompt diagnosis and understanding tissue remodeling are crucial for effective treatment beyond current therapies.

Keywords:
Eosinophilic esophagitisfibrosismyofibroblast activationtherapiestissue remodeling

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Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
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Published on: March 22, 2017

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Last Updated: Jun 21, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Published on: May 10, 2024

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus.
  • It is characterized by esophageal dysfunction, tissue eosinophilia, and often linked to food impaction and dysphagia.
  • Untreated EoE can lead to fibrostenosis, a complex remodeling process involving fibrosis and stenosis.

Purpose of the Study:

  • To review the need for prompt diagnosis and treatment of EoE.
  • To identify histologic parameters and biomarkers for predicting disease progression to tissue remodeling.
  • To summarize current research on cellular and molecular mediators driving tissue remodeling in EoE.

Main Methods:

  • Literature review of current research on EoE pathogenesis and treatment.
  • Analysis of cellular and molecular pathways involved in esophageal tissue remodeling.
  • Discussion of diagnostic and therapeutic challenges in managing EoE.

Main Results:

  • Current therapies like corticosteroids and monoclonal antibodies may not fully reverse EoE-associated fibrosis.
  • Tissue remodeling in EoE involves complex pathways beyond type 2 immunity.
  • Identifying progression biomarkers and understanding remodeling mediators are critical research areas.

Conclusions:

  • Early diagnosis and intervention are essential for managing EoE and preventing irreversible fibrostenosis.
  • Further research into the multifaceted mechanisms of tissue remodeling is needed to develop more effective treatments.
  • Targeting key cellular and molecular mediators may offer new therapeutic strategies for EoE.