Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
Probiotics01:22

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurophysiological correlates of taVNS-mediated cognitive enhancement.

Clinical neurophysiology practice·2026
Same author

Trends and seasonal variation in the incidence and prevalence of irritable bowel syndrome in Korea: a multicenter OMOP CDM study.

Frontiers in public health·2026
Same author

A multiverse approach to heat-evoked skin conductance analysis: evaluating the influence of analytic pipeline on associations between skin conductance and pain.

Pain·2026
Same author

Listen to your inner body: embodied emotions in predictive neuroscience and traditional East Asian medicine.

Frontiers in human neuroscience·2026
Same author

Prospective entry criteria for newly named acupoints: A conceptual framework.

Integrative medicine research·2026
Same author

Altered brain connectivity in sensory and motor cortices underlying atopic dermatitis.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same journal

Corrigendum to "Huangqi Jianzhong decoction inhibits CRC invasion through the modulation of BCLAF1-mediated glycolysis" [J. Ethnopharmacol. (2026) 121940].

Journal of ethnopharmacology·2026
Same journal

Cortex Phellodendri total alkaloids ameliorate ulcerative colitis by restoring intestinal barrier integrity via modulation of the ER-mitochondria axis.

Journal of ethnopharmacology·2026
Same journal

Panax quinquefolius saponins promote remyelination via orchestrating HMGCS1-NPC1-MAL-mediated lipid metabolism and rebalancing JAK-STAT signaling in a cuprizone-induced demyelination model.

Journal of ethnopharmacology·2026
Same journal

The Modulation of RAGE by Natural Products and Traditional Medicines: Opening Promising Perspectives for Inflammatory Diseases.

Journal of ethnopharmacology·2026
Same journal

Parinari curatellifolia aqueous leaf-bark extract mitigates chronic Plasmodium berghei-induced bone loss in Wistar rats through anti-inflammatory and osteoregenerative mechanisms.

Journal of ethnopharmacology·2026
Same journal

Corrigendum to "Nobiletin from Citrus reticulata Blanco alleviates pulmonary fibrosis through inhibiting the PI3K/AKT pathway and epithelial-mesenchymal transition" [J. Ethnopharmacol. 349 (2025) 119965].

Journal of ethnopharmacology·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

Multi-herb formulations modulating gut microbiota: A systematic review and data-driven analysis.

Min-Seok Cho1, In-Seon Lee2, Junsuk Kim3

  • 1Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.

Journal of Ethnopharmacology
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

This study maps how multi-herb formulations affect the gut microbiota, identifying specific herbs like Scutellaria baicalensis and Zingiber officinale linked to microbial shifts. These findings offer a foundation for developing standardized ethnopharmacological therapies.

Keywords:
EthnopharmacologyGut microbiotaMachine learningNetwork pharmacologySystematic reviewTraditional East Asian medicine

Related Experiment Videos

Last Updated: Jun 21, 2026

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

Area of Science:

  • Microbiome research
  • Pharmacology
  • Ethnobotany

Background:

  • Multi-herb formulations are complex and widely used in traditional medicine to influence the gut microbiota.
  • Identifying reproducible herb-microbiota associations across diverse clinical settings presents a significant challenge.

Purpose of the Study:

  • To systematically synthesize human clinical evidence on multi-herb formulation effects on gut microbiota.
  • To identify specific herbal components associated with directional microbial shifts.

Main Methods:

  • Systematic review and data-driven analysis of 29 clinical trials (954 participants).
  • Binarization strategy for statistically significant directional microbial shifts (+1 increase, -1 decrease).
  • Extreme Gradient Boosting (XGBoost) with SHapley Additive exPlanations (SHAP) for constituent analysis, validated using Leave-One-Study-Out (LOSO) cross-validation.

Main Results:

  • Leave-One-Study-Out (LOSO) validation achieved 0.84 accuracy and 0.42 macro F1-score, showing cross-study pattern recognition despite data heterogeneity.
  • Formulations with Scutellaria baicalensis were linked to reduced Escherichia-Shigella in neuropsychiatric contexts.
  • Zingiber officinale formulations showed associations with both increases and decreases in specific gut taxa across various conditions.

Conclusions:

  • Provides an evidence-based map of multi-herb formulation-induced gut microbiota modulation.
  • Identified hypothesis-generating patterns that overcome individual study variations, prioritizing rigorous validation.
  • Establishes a foundation for future metagenomic research and standardized ethnopharmacological therapies.