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C26:0-lysophosphatidylcholine in X-linked adrenoleukodystrophy.

Yorrick R J Jaspers1, Inge M E Dijkstra1, Marc Engelen2

  • 1Laboratory Genetic Metabolic Diseases, Department of Laboratory Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam Neuroscience, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands.

Pharmacology & Therapeutics
|June 19, 2026
PubMed
Summary

X-linked adrenoleukodystrophy (ALD) is diagnosed using C26:0-lysophosphatidylcholine (LPC(26:0)), a marker that also predicts disease severity and aids in monitoring treatment effectiveness. This biomarker offers improved accuracy over traditional methods.

Keywords:
BiomarkerDisease severityLipidomicsLysophosphatidylcholineNewborn screeningPrognosisTherapeutics

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