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Research advances in claudin-1 in the eye
Lei Wang1, Chaoyang Zhang2, Na Li3
1Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 215000, China; Department of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 215000, China.
Experimental Eye Research
|June 19, 2026
Summary
Claudin-1 is vital for eye tissue integrity and barrier function. Its dysregulation is linked to various eye diseases, offering potential therapeutic targets for barrier modulation and drug delivery.
Area of Science:
- Ophthalmology
- Cell Biology
- Molecular Biology
Background:
- Claudin-1 is a transmembrane protein crucial for tight junctions, paracellular barrier formation, and cellular polarity.
- In ocular tissues like the cornea and retina, claudin-1 maintains transparency, blood-retinal barrier integrity, and retinal homeostasis.
Purpose of the Study:
- To synthesize current knowledge on claudin-1's spatial distribution and physiological roles in ocular tissues.
- To evaluate claudin-1's involvement in ocular pathologies and its therapeutic potential.
Main Methods:
- Comprehensive literature review of spatial distribution and physiological roles of claudin-1.
- Critical evaluation of mechanistic and translational advances in claudin-1 research.
- Assessment of claudin-1's therapeutic potential as a molecular target and drug delivery facilitator.
Main Results:
- Claudin-1 exhibits tissue-specific expression in the cornea and retina, essential for their functions.
- Claudin-1 dysregulation is implicated in diverse anterior segment and retinal diseases.
- Emerging evidence highlights claudin-1's potential in therapeutic strategies for ocular conditions.
Conclusions:
- Claudin-1 plays a fundamental role in maintaining ocular tissue integrity and barrier function.
- Dysregulation of claudin-1 is associated with a wide range of ophthalmic diseases.
- Claudin-1 presents promising therapeutic avenues for treating eye diseases and enhancing drug delivery.
