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Related Experiment Video

Updated: Jun 21, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Diffuse large B-cell lymphoma masquerading as multiple myeloma.

Steven Luo1, Rui Zhao2

  • 1School of Clinical Medicine, University of Cambridge, Cambridge, UK sl2055@cam.ac.uk.

BMJ Case Reports
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

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A misdiagnosed case initially treated for multiple myeloma was reclassified as diffuse large B-cell lymphoma after bone marrow assessment. Effective chemotherapy led to a good response and sustained remission, highlighting the importance of accurate diagnosis.

Area of Science:

  • Hematology
  • Oncology
  • Internal Medicine

Background:

  • Multiple myeloma and diffuse large B-cell lymphoma (DLBCL) can present with overlapping symptoms.
  • Accurate differentiation is crucial for appropriate treatment and patient outcomes.

Purpose of the Study:

  • To report a case of misdiagnosed multiple myeloma initially treated as such.
  • To highlight the diagnostic challenge and successful management of DLBCL after initial misdiagnosis.

Main Methods:

  • Clinical presentation and initial laboratory findings suggestive of multiple myeloma.
  • Bone marrow biopsy for definitive diagnosis.
  • Chemotherapy regimens for DLBCL.

Main Results:

Keywords:
Cancer interventionHaematology (drugs and medicines)Haematology (incl blood transfusion)Malignant and Benign haematology

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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

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Last Updated: Jun 21, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Published on: March 30, 2018

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

  • Initial treatment for multiple myeloma was ineffective.
  • Bone marrow biopsy revealed B-cell lymphoma, not plasma cells.
  • Subsequent DLBCL-specific chemotherapy led to a good response and sustained remission.

    • Conclusions:

    • Accurate diagnosis through bone marrow assessment is critical for hematologic malignancies.
    • DLBCL can mimic multiple myeloma, necessitating careful diagnostic evaluation.
    • Timely adjustment of treatment based on definitive diagnosis improves patient prognosis.