Related Experiment Video
Updated: Jun 21, 2026
07:30
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Interventions for Silent Brain Infarction and Perioperative Neurocognitive Disorders in Cardiovascular Surgery
Lu Wang1, Shu Li2,3, Philip James Devereaux4
1Department of Anaesthesiology,Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
BMJ Open
|June 19, 2026
Summary
This study investigates neuroprotective anesthesia targets to prevent silent brain infarction (SBI) and neurocognitive disorders after cardiac surgery. Findings aim to establish new preventive strategies for these common complications.
Area of Science:
- Cardiology
- Neurology
- Anesthesiology
Background:
- Silent brain infarction (SBI) and perioperative neurocognitive disorders (PND) are common after cardiac surgery.
- Current preventive strategies are limited due to insufficient evidence.
Purpose of the Study:
- To evaluate the efficacy of neuroprotective anesthesia targets in reducing SBI and PND.
- To establish evidence-based preventive strategies for patients undergoing cardiac surgery.
Main Methods:
- A multicenter, prospective, randomized controlled trial with 912 participants undergoing cardiac surgery with cardiopulmonary bypass.
- Intervention group received neuroprotective anesthesia targets; control group received routine care.
- Primary outcome: 7-day incidence of new-onset SBI. Key secondary outcome: 30-day incidence of PND.
Main Results:
- The study is ongoing, and results are pending.
- Data collection and analysis are underway to determine the primary and secondary outcomes.
Conclusions:
- The findings will inform clinical practice regarding the prevention of neurological complications after cardiac surgery.
- This trial aims to provide crucial evidence for optimizing patient outcomes in cardiac surgery.
