Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transducer Mechanism: Nuclear Receptors

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:

NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

Regulation of Food Intake

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Regulation of the Unfolded Protein Response

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diet, mycobiome and virome: from mucosal immunity to gut-brain axis regulation.

Frontiers in nutrition·2026

Same author

Sleep and aging: The role of DNA methylation.

Experimental gerontology·2026

Same author

Crosstalk Between Inflammation and Cellular Senescence in Osteoarthritis: Modulatory Actions of Olive Oil and Its Bioactive Compounds.

Mediators of inflammation·2026

Same author

Beyond ethanol: wine, biological aging, and the Mediterranean context.

International journal of public health·2026

Same author

NRF2 as a guardian of health: from an ancient survival pathway to a modern therapeutic target.

Redox biology·2026

Same author

Generation and validation of C-terminal LRP8 antibodies for detecting processed intracellular fragments.

BioTechniques·2026

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

Nrf2 in obesity: Mechanisms, models, and bioactive modulators.

Irina N Shalova¹, Alessandro Medoro², Sergio Davinelli²

¹Department of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, 5 Piazzale Aldo Moro, Rome 00185, Italy.

Obesity Research & Clinical Practice

|June 19, 2026

Summary

Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a complex role in obesity by influencing inflammation and metabolism. Modulating Nrf2 shows therapeutic potential for obesity, but requires further research for safe and effective strategies.

Keywords:

Bioactive compounds Chronic inflammation Lipid metabolism Nrf2 Obesity Oxidative stress

More Related Videos

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Related Experiment Videos

Last Updated: Jun 21, 2026

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Area of Science:

Biochemistry
Metabolic disease research
Cellular biology

Background:

Obesity is a chronic disease linked to inflammation, oxidative stress, and metabolic dysfunction.
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of cellular defense mechanisms.
Nrf2 signaling is increasingly recognized for its role in metabolic processes relevant to obesity.

Purpose of the Study:

To review the mechanistic roles of Nrf2 in obesity.
To discuss the dual effects of Nrf2 modulation in obesity.
To summarize bioactive compounds targeting Nrf2 for anti-obesity effects.

Main Methods:

Literature review of genetic and pharmacological models.
Analysis of Nrf2's involvement in inflammation, oxidative stress, and metabolism.
Summary of preclinical and clinical findings on Nrf2 modulators.

Main Results:

Nrf2 influences adipogenesis, lipid metabolism, and inflammation in obesity.
Nrf2 modulation can have both protective and detrimental effects on obesity-related pathways.
Several bioactive compounds activate Nrf2 and show anti-obesity potential, with some in clinical trials.

Conclusions:

Nrf2 signaling is a complex target for obesity intervention.
Bioactive compounds targeting Nrf2 offer promising therapeutic avenues.
Further mechanistic and clinical studies are needed to establish safe and effective Nrf2-based obesity treatments.