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Related Concept Videos

Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

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Related Experiment Video

Updated: Jun 21, 2026

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

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Published on: October 7, 2021

Autonomic Nervous System Phenotyping Across Chronic Demyelinating Peripheral Neuropathies: A Comparative Study.

Bogdan Bjelica1,2, Teodora Todorovic3, Ivo Bozovic3

  • 1Department of Neurology, Hannover Medical School, Hannover, Germany.

Journal of the Peripheral Nervous System : JPNS
|June 19, 2026
PubMed
Summary

Autonomic nervous system (ANS) dysfunction is common in chronic inflammatory demyelinating polyneuropathy (CIDP), MGUS-associated neuropathy (MGUS-PNP), and Charcot-Marie-Tooth disease Type 1A (CMT1A). These neuropathies show distinct ANS symptom patterns, impacting overall disability.

Keywords:
Charcot–Marie–Tooth disease Type 1Aautonomic dysfunctionchronic demyelinating polyneuropathychronic inflammatory demyelinating polyneuropathyhereditary neuropathy with liability to pressure palsiesmonoclonal gammopathy of undetermined significance‐associated neuropathy

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Last Updated: Jun 21, 2026

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
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A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
07:30

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

Published on: November 9, 2017

Area of Science:

  • Neurology
  • Autonomic Neuroscience
  • Clinical Research

Background:

  • Autonomic nervous system (ANS) involvement is increasingly recognized in various peripheral neuropathies.
  • Phenotyping ANS dysfunction is crucial for understanding disease mechanisms and clinical impact.

Purpose of the Study:

  • To systematically evaluate and compare autonomic nervous system involvement across different peripheral neuropathy subtypes.
  • To investigate the relationship between autonomic dysfunction and overall disability in these conditions.

Main Methods:

  • Utilized the SCales for Outcomes in Parkinson's Disease-Autonomic Dysfunction (SCOPA-AUT) to assess autonomic symptoms.
  • Employed established scales like MRC, INCAT, and ONLS for muscle strength and functional disability assessment.
  • Included 343 participants: 98 with CIDP, 51 with MGUS-PNP, 51 with CMT1A, 18 with HNPP, and 125 healthy controls.

Main Results:

  • Patients with CIDP, MGUS-PNP, and CMT1A demonstrated significantly higher SCOPA-AUT scores compared to healthy controls (p < 0.01).
  • Observed distinct, disease-specific patterns of ANS symptoms across the neuropathy groups.
  • Autonomic symptom burden was independently associated with overall disability in MGUS-PNP and CMT1A (p < 0.05).
  • Active CIDP patients exhibited a greater autonomic symptom burden than inactive cases (p = 0.042).

Conclusions:

  • CIDP, MGUS-PNP, and CMT1A patients present significant autonomic symptom burden with unique ANS profiles.
  • Autonomic dysfunction is a relevant clinical feature in immune-mediated and hereditary neuropathies.
  • Further research is needed to elucidate the clinical and prognostic implications of autonomic dysfunction in these neuropathies.