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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...
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T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Related Experiment Video

Updated: Jun 21, 2026

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Long Non-coding RNA TLX1NB Regulates Inflammatory Response in Periodontitis by Interacting With Matrix

Shouxiang Yang1, Wanting Yuan1, Ziqiong Yang1

  • 1College & Hospital of Stomatology, Anhui Province Key Laboratory of Oral Diseases Research, Anhui Medical University, Hefei, 230032, China.

Inflammation
|June 19, 2026
PubMed
Summary

Long non-coding RNA T cell leukemia homeobox 1 neighbor (TLX1NB) is upregulated in periodontitis. Reducing TLX1NB alleviates inflammation and dysfunction by regulating matrix metalloproteinase 8 (MMP8) and NF-κB signaling.

Keywords:
InflammationMMP8NF-κBPeriodontitislncRNA TLX1NB

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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Published on: January 21, 2020

Related Experiment Videos

Last Updated: Jun 21, 2026

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Area of Science:

  • Molecular Biology
  • Immunology
  • Periodontal Disease Research

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators of inflammatory processes.
  • Periodontitis involves complex inflammatory responses impacting oral health.

Purpose of the Study:

  • To investigate the role of lncRNA TLX1NB in periodontitis.
  • To elucidate the regulatory mechanism of TLX1NB on MMP8 in periodontal inflammation.

Main Methods:

  • Transcriptome sequencing and RT-qPCR for TLX1NB expression analysis.
  • In vitro studies using TNF-α-stimulated human gingival fibroblasts (HGFs).
  • FISH, cellular fractionation, RNA pull-down, and RIP assays for mechanistic insights.

Main Results:

  • TLX1NB was significantly upregulated in periodontitis tissues and TNF-α-stimulated HGFs.
  • TLX1NB knockdown reduced pro-inflammatory cytokines (IL-1β, IL-6, IL-8) and enhanced HGF proliferation.
  • TLX1NB directly interacts with MMP8, cooperatively regulating inflammation and apoptosis via NF-κB signaling.

Conclusions:

  • TLX1NB is a crucial mediator of periodontal inflammation and cellular dysfunction.
  • Targeting TLX1NB offers a potential therapeutic strategy for periodontitis treatment.
  • The TLX1NB-MMP8 axis influences NF-κB signaling in periodontal disease.