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Updated: Jun 21, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

Alternative splicing rewires breast cancer and opens therapeutic avenues

Yuhan Jin1, Yiran Liang1, Mahsa Maghsoudy Kasvaei2

  • 1Department of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Wenhua Xi Road No. 107, Jinan, Shandong, 250012, P.R. China.

Cell Communication and Signaling : CCS
|June 19, 2026
PubMed

Insights

Alternative splicing (AS) significantly contributes to breast cancer complexity and progression by generating diverse mRNA isoforms. Understanding AS mechanisms offers potential for novel diagnostic and therapeutic strategies in precision oncology.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer displays significant heterogeneity in subtypes, metastasis, and treatment response.
  • Post-transcriptional regulation, especially alternative splicing (AS), amplifies proteomic diversity and influences oncogenic processes.
  • AS generates multiple mRNA isoforms, impacting cell migration, metabolism, immune evasion, and drug resistance.

Purpose of the Study:

  • To review the mechanistic basis of AS regulation in breast cancer.
  • To synthesize recent findings on AS-driven oncogenic pathways.
  • To evaluate the clinical and translational potential of AS in breast cancer.

Main Methods:

  • Systematic mapping of AS landscapes using high-throughput sequencing.
  • Bioinformatic analysis of AS patterns in breast cancer.
  • Literature review synthesizing current research on AS mechanisms and clinical applications.

Main Results:

  • AS is a key driver of breast cancer complexity, influencing critical oncogenic pathways.
  • AS signatures show promise as biomarkers for molecular subtyping and prognosis.
  • Targeting AS offers potential for novel splice-switching therapeutics.

Conclusions:

  • Alternative splicing plays a crucial role in breast cancer development and progression.
  • AS signatures hold translational value for clinical applications like diagnostics and therapeutics.
  • Overcoming challenges like tumor heterogeneity is essential for leveraging AS in precision oncology.
Keywords:
Alternative splicingBiomarkerBreast cancerSplicing factorTherapeutic target

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