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  3. Riboregulation: A Non-canonical Tau Function.
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  3. Riboregulation: A Non-canonical Tau Function.

Related Experiment Video

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

Riboregulation: a non-canonical tau function.

Katherine R LeBlanc1,2,3, Randall J Eck3,4, Sarah J Benbow3,5

  • 1Molecular & Cellular Biology Graduate Program, University of Washington, Seattle, WA, 98195, USA.

Molecular Neurodegeneration
|June 19, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Tau protein, implicated in neurodegenerative diseases, binds to RNA and impacts RNA metabolism. Further research is needed to understand tau

Keywords:
Alzheimer’s diseaseRNA metabolismTauopathy

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Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
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Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
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Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

Related Experiment Videos

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
11:26

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Published on: December 10, 2014

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Tau protein is involved in microtubule stabilization.
  • Tau has been observed to bind RNA, with recent studies suggesting a higher affinity for RNA than microtubules.
  • Tau dysfunction is linked to disruptions in RNA metabolism in neurodegenerative diseases.

Purpose of the Study:

  • To review the evidence for tau's role in RNA biology.
  • To highlight tau's function as an RNA binding protein.
  • To discuss the implications of tau-RNA interactions in both physiological and disease states.

Main Methods:

  • Literature review of existing studies on tau protein and RNA interactions.
  • Analysis of research on tau's role in RNA metabolism, including splicing, translation, and RNA degradation.
  • Examination of tau aggregate formation and its impact on RNA sequestration.

    • Main Results:

    • Tau protein exhibits significant RNA binding capabilities.
    • Tau dysfunction disrupts critical RNA metabolic processes such as mRNA splicing and translation.
    • Tau aggregates sequester various RNA species and RNA-binding proteins, contributing to disease pathology.

    Conclusions:

    • Tau is increasingly recognized as a key RNA binding protein.
    • Understanding tau's direct RNA binding is crucial for elucidating its physiological roles and disease-related functions.
    • The complex structures of tau in different disease states present challenges for fully understanding its impact on RNA regulation.