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Updated: Jun 21, 2026

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
06:50

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions

Published on: January 26, 2024

Generating models for isoform-specific PKM-KIBRA interactions with BIFC, stabilization and AlphaFold 3.

Edna Amoah1, Tyler W Dunn1, Larissa Ferguson1

  • 1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.

Molecular Brain
|June 19, 2026
PubMed
Summary

Aplysia Kidney/Brain protein (KIBRA) interactions with protein kinase M (PKM) variants were studied. Some KIBRA variants bind PKM but do not stabilize it, suggesting inhibition is key for memory maintenance.

Keywords:
Atypical protein kinase CMemory retentionPKCPersistent protein kinasesProtein complexesSynaptic plasticity

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