Related Experiment Video

Updated: Jun 23, 2026

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children
04:55

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Published on: September 11, 2018

Clinical characteristics and predictors for the presence of pediatric intussusception secondary to pathological lead

Yuan-Yang Yu1, Yi-Xuan Wei1, Zhong-Zhe Ren1

  • 1Department of Pediatric Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109# Xueyuan West Road, Wenzhou, 325027, China.

Pediatric Surgery International
|June 20, 2026
PubMed

Insights

This study identified key predictors for intussusception caused by pathological lead points in children. Older age, recurrence, small-intestinal location, elevated thrombocytocrit, and ascites increase risk, while hematochezia and vomiting decrease it.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Medical Diagnostics

Background:

  • Intussusception is a common surgical emergency in children.
  • Pathological lead points (PLPs) are identifiable causes in a subset of cases.
  • Understanding predictors of PLP-related intussusception is crucial for diagnosis and management.

Purpose of the Study:

  • To analyze clinical characteristics of intussusception secondary to PLPs.
  • To identify independent predictors associated with PLP-induced intussusception.

Main Methods:

  • Retrospective study of 575 children surgically treated for intussusception (2010-2025).
  • Patients categorized into PLP and non-PLP groups.
  • Comparison of demographic, clinical, laboratory, imaging, surgical, and pathological data.

Main Results:

  • 126 (21.9%) children had PLPs; 449 (78.1%) had idiopathic intussusception.
  • Independent predictors for PLPs included: older age, absence of hematochezia/vomiting, recurrence, small-intestinal location, elevated thrombocytocrit (PCT), and presence of ascites.
  • PLP etiologies included Meckel's diverticulum, duplications, polyps, tumors, and inflammatory conditions.

Conclusions:

  • Older age, intussusception recurrence, small-intestinal intussusception, elevated PCT, and ascites are significant predictors of PLPs.
  • Absence of hematochezia and vomiting are also associated with PLPs.
  • These predictors can aid in risk stratification and surgical decision-making for intussusception.
Abstract

Keywords:
IntussusceptionPathological lead pointsPediatricPredictors

Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Intestinal Obstruction I: Introduction01:29

Intestinal Obstruction I: Introduction

Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...