Related Experiment Video

Updated: Jun 23, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

A local-to-distant shift in dynamic brain connectivity marks early Alzheimer's risk

Andrea Coca-Pulido1, Patricio Solis-Urra2,3, Oren Contreras-Rodríguez4,5,6,7

  • 1Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. acocapulido@ugr.es.

Geroscience
|June 20, 2026
PubMed
Summary

Alzheimer's disease risk markers like amyloid-beta and APOE4 are linked to altered brain connectivity in normal aging. This shift from local to distant connectivity may signal early network vulnerability and aid risk monitoring.

Keywords:
APOE4 statusAmyloid-betaBlood-based biomarkersNeurofilament light chainResting-state fMRI

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