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Updated: Jun 23, 2026

Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay
Published on: January 12, 2022
Cis-regulatory strategies in developmental patterning
Jack Pc Williams1, M Joaquina Delás2
1Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: https://twitter.com/jackpcw.bsky.social.
None:
Cell fate choice during development generates the large cell type diversity required to build the complex tissues and organs in our bodies. These cell fate decisions involve the cell-type-specific regulation of gene expression. At the chromatin level, this differential gene expression can be achieved by distinct strategies, which either involve changes in accessibility or solely differential transcription factor binding. In this review, we summarize these two strategies and their use during spatial and temporal patterning. We describe how the generation of cell type diversity in tissues can involve the integration of both strategies and discuss the implications for cell fate choice associated with each.
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