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Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Updated: Jun 23, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Patient Perspectives on Reirradiation for Recurrent Cancer, to Inform Future Clinical Trial Design.

F Slevin1, S Kendal2, A L Appelt1

  • 1Radiotherapy Research Group, Leeds Institute of Medical Research, University of Leeds, Leeds, West Yorkshire, UK; Leeds Teaching Hospitals NHS Trust, Leeds, West Yorkshire, UK.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|June 20, 2026
PubMed
Summary

Patient and carer experiences with reirradiation for recurrent cancers highlight psychological impacts and oncologist influence on decisions. Future clinical trials for reirradiation should consider patient preferences for advanced technologies and active treatment arms.

Keywords:
Clinical trialsinterviewsproton beam therapyre-irradiationreirradiation

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Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
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Published on: October 18, 2011

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Last Updated: Jun 23, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
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Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
10:10

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

Area of Science:

  • Oncology
  • Radiation Oncology
  • Patient-Centered Care

Background:

  • Growing interest in reirradiation for recurrent or new primary cancers in previously irradiated areas.
  • Need for high-quality studies to evaluate the efficacy and patient experience of reirradiation.
  • Limited understanding of patient and carer perspectives on reirradiation, clinical trial design, and advanced technologies.

Purpose of the Study:

  • To explore patient and carer perspectives on reirradiation for recurrent cancers.
  • To understand views on future clinical trial design for reirradiation studies.
  • To assess opinions regarding the role of advanced technologies in reirradiation.

Main Methods:

  • Semi-structured interviews conducted with 11 patients who underwent reirradiation and 5 of their carers.
  • Thematic analysis used to analyze interview data.
  • Patients were approached by their oncologists during follow-up.

Main Results:

  • Five key themes emerged: psychological impact of recurrence, influences on reirradiation decision-making, experience of reirradiation, future clinical trial design considerations, and advanced technology considerations.
  • Patients and carers reported significant psychological distress from cancer recurrence and strong reliance on oncologist recommendations for reirradiation decisions, with no reported decision regret.
  • Patients expressed potential willingness to travel for reirradiation with advanced technologies like proton beam therapy, contingent on personal/financial circumstances; non-active treatment arms in trials may be less acceptable.

Conclusions:

  • Patient and carer insights provide valuable perspectives on reirradiation for recurrent cancers.
  • Findings will inform the design of future clinical trials, particularly concerning patient preferences for treatment options and advanced technologies.
  • Understanding patient-centered factors is crucial for optimizing reirradiation strategies and trial development.