Predictive value of serum miR‑670‑3p for post‑stroke cognitive impairment in aging patients with acute ischemic...

Post-stroke cognitive impairment (PSCI) is a frequent and severe complication that commonly occurs in aging patients with acute ischemic stroke (AIS).

To investigate serum miR-670-3p expression in aging AIS patients and evaluate its predictive performance for PSCI, and to explore the underlying mechanism.

A total of 115 aging patients with AIS and 60 age- and sex-matched healthy volunteers were enrolled in this study. All AIS patients were to divide them into PSCI and non-PSCI groups. RT-qPCR was applied to measure the expression levels of serum miR-670-3p and HMGB1 mRNA. ROC curve and logistic regression analyses were conducted to assess the predictive value of miR-670-3p for PSCI. For in vitro assays, SH-SY5Y cells were utilized to establish an OGD/R model, which mimics cerebral ischemia-reperfusion injury.

Serum miR-670-3p was significantly decreased in AIS, especially in patients with PSCI. miR-670-3p was significantly correlated with NIHSS, MoCA and MMSE scores, with an AUC value of 0.842 for predicting post-stroke cognitive impairment, and served as an influencing factor. In vitro experiments revealed that miR-670-3p directly targeted HMGB1 and relieved neuronal injury, oxidative stress and inflammation induced by oxygen-glucose deprivation/reperfusion.

Serum miR-670-3p serves as a promising non-invasive predictive biomarker for PSCI in aging AIS patients. miR-670-3p/HMGB1 axis may serve as a new potential therapeutic target for cognitive impairment secondary to ischemic stroke.