A randomized crossover clinical trial of the Deseyne contact lens for presbyopia with extended depth of focus

To evaluate the visual performance of a new daily wear presbyopia contact lens (Deseyne contact lens for presbyopia with extended depth of focus).

This was a randomized, crossover, and nondispensing clinical trial. Seventy-eight presbyopic (45-70 years, mean = 53.9 years) habitual soft contact lens wearers were recruited with spherical refractive errors between -6.00 and +4.00 D and less than 1.25 D astigmatism. Subjects were fitted bilaterally with the Deseyne lens and a control monofocal contact lens and randomized as to which of the study lenses would be tested first. Effectiveness measures included monocular lens-induced depth of focus testing-the primary effectiveness measure-and monocular distance, intermediate, and near visual acuity. Contrast sensitivity was also measured at mesopic luminance with and without glare.

Mean monocular distance visual acuity was 0.00 ± 0.07 and -0.07 ± 0.07 logMAR with the Deseyne and control lens, respectively. The corresponding mean monocular intermediate visual acuity was +0.02 ± 0.11 and +0.16 ± 0.14 logMAR and monocular near visual acuity was +0.20 ± 0.11 and +0.35 ± 0.17 logMAR. Mean depth of focus was 2.22 ± 0.78 D with the Deseyne lens and 1.44 ± 0.67 D with the monofocal control. The mean extended depth of focus (95% CI) was thus 0.78 (0.63, 0.93) D. Contrast sensitivity was significantly lower with the Deseyne lens at 3, 6, and 12 cycles per degree with and without glare.

The Deseyne contact lens for presbyopia with extended depth of focus extends the depth of focus of the eye and thus improves intermediate and near visual acuity.