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Updated: Jun 23, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
Beyond one gene, one target: Next-generation precision oncology.
Vivek Subbiah1, Razelle Kurzrock2
1Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Single biomarker-drug strategies in precision oncology show limited response rates. Future advancements require individualized combination therapies tailored to cancer complexity and enhanced biomarker matching for better patient outcomes.
Area of Science:
- Oncology
- Genomics
- Pharmacology
Background:
- The Drug Rediscovery Protocol implemented nationwide biomarker-guided, off-label precision oncology.
- Current outcomes with single biomarker-drug strategies show a plateau, with response rates around 15.7%.
Purpose of the Study:
- To evaluate the efficacy of single biomarker-drug strategies in precision oncology.
- To highlight the need for advanced therapeutic approaches in complex cancers.
Main Methods:
- Analysis of nationwide data from the Drug Rediscovery Protocol.
- Review of outcomes from a decade of precision oncology studies.
Main Results:
- A response rate of 15.7% was observed, consistent with previous studies.
- A ceiling effect was identified for single biomarker-drug combinations.
Conclusions:
- Single biomarker-drug approaches in precision oncology have limitations.
- Future efficacy gains depend on individualized combination therapies and comprehensive biomarker matching, aligning with the I-PREDICT framework.
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