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Related Concept Videos

Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Cell-surface Signaling01:21

Cell-surface Signaling

Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.

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Related Experiment Video

Updated: Jun 23, 2026

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

Pathway-centric visualization of cell-cell communication in single-cell transcriptomics data.

Sidrah Maryam1, Martin Manolov2, Rafael Kramann1

  • 1Department of Medicine 2, Uniklinik, Aachen, NRW, Germany.

NPJ Systems Biology and Applications
|June 20, 2026
PubMed
Summary
This summary is machine-generated.

scVizComm is a new web portal for visualizing cell-cell communication networks from single-nuclei transcriptomics data. It enables pathway-centric analysis without programming, aiding in the study of complex biological interactions.

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Comprehensive Spatial Profiling of Species-agnostic Transcriptomes via Stereo-seq

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Transcriptome Analysis of Single Cells
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Transcriptome Analysis of Single Cells

Published on: April 25, 2011

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Last Updated: Jun 23, 2026

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

Comprehensive Spatial Profiling of Species-agnostic Transcriptomes via Stereo-seq
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Comprehensive Spatial Profiling of Species-agnostic Transcriptomes via Stereo-seq

Published on: October 31, 2025

Transcriptome Analysis of Single Cells
07:27

Transcriptome Analysis of Single Cells

Published on: April 25, 2011

Area of Science:

  • Computational Biology
  • Bioinformatics
  • Systems Biology

Background:

  • Single-nuclei transcriptomics (snRNA-seq) is crucial for studying cell-cell communication.
  • Existing tools lack user-friendly, non-programmatic interfaces for analyzing ligand-receptor interactions.
  • Current methods often fail to incorporate molecular pathways in downstream receptor signaling analysis.

Purpose of the Study:

  • To develop scVizComm, an interactive web portal for visualizing ligand-receptor networks.
  • To enable pathway-centric analysis of cell-cell communication from snRNA-seq data.
  • To provide a non-programmatic tool for exploring intercellular communication.

Main Methods:

  • Development of scVizComm, a ShinyApp-based web portal.
  • Integration of pre-calculated, pathway-centric cell-cell communication results.
  • Utilized human kidney, heart, and mouse anterior brain snRNA-seq datasets.

Main Results:

  • Demonstrated scVizComm's utility in analyzing fibrosis-related pathways in human kidney and heart data.
  • Showcased spatial exploration of ligand-receptor expression in mouse brain data.
  • Facilitated interactive visualization and prioritization of cell-cell communication analyses.

Conclusions:

  • scVizComm offers an accessible platform for interactive visualization of cell-cell communication.
  • The tool supports pathway-centric prioritization, enhancing biological insights from snRNA-seq data.
  • scVizComm empowers researchers to explore complex intercellular signaling networks efficiently.