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Severe gastrointestinal involvement is associated with renal manifestations in pediatric IgA vasculitis: a

Thuy Trang Mai1, Thu Ha Le2,3

  • 1Department of Nephrology and Endocrinology, Children's Hospital 1, Ho Chi Minh City, Vietnam.

BMC Pediatrics
|June 20, 2026
PubMed

Insights

Severe gastrointestinal issues in pediatric IgA vasculitis (IgAV) may signal a higher risk of early kidney problems. Close monitoring of kidney function is advised for children with significant GI symptoms.

Area of Science:

  • Pediatric Nephrology
  • Pediatric Rheumatology
  • Gastroenterology

Background:

  • Gastrointestinal (GI) manifestations are frequent in pediatric IgA vasculitis (IgAV).
  • The link between GI symptoms and kidney involvement in pediatric IgAV is not fully understood.
  • Early identification of children at risk for renal complications is crucial.

Purpose of the Study:

  • To investigate the association between gastrointestinal manifestations and renal involvement in pediatric IgA vasculitis.
  • To identify risk factors for renal complications in children with IgAV.

Main Methods:

  • Retrospective single-center cohort study of children diagnosed with IgAV.
  • Analysis of clinical characteristics, GI manifestations, and renal outcomes (hematuria/proteinuria).
  • Multivariable logistic regression and sensitivity analyses to identify associated factors.

Main Results:

  • Severe GI involvement was significantly associated with renal involvement in pediatric IgAV (aOR 4.34, p=0.007).
  • Of 44 patients with follow-up, 43.2% exhibited renal involvement.
  • 82.4% of patients experienced GI manifestations, with 55.4% having severe involvement.

Conclusions:

  • Severe gastrointestinal involvement may predict early renal manifestations in pediatric IgAV.
  • Enhanced renal monitoring is suggested for pediatric IgAV patients with severe GI symptoms.
  • Further multicenter studies with extended follow-up are necessary to validate these findings.
Abstract

Keywords:
Gastrointestinal involvementHenoch-Schönlein PurpuraIgA vasculitisPediatric vasculitisRenal involvement

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