Related Experiment Video
Updated: Jun 23, 2026
12:09
Methods for Intravenous Self Administration in a Mouse Model
Published on: December 8, 2012
Contingency management for adherence to injectable medication for substance use disorders
Jay A Gorman1, Victoria E Ameral2, Brent E Abrams3
1VISN 1 Mental Illness Research, Education, and Clinical Center (MIRECC), VA Bedford Healthcare System, Bedford, MA; Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Journal of Substance Use and Addiction Treatment
|June 21, 2026
Summary
Contingency Management (CM) significantly improved adherence to injectable medications for substance use disorders. Veterans receiving CM had substantially higher medication doses compared to those without CM.
Area of Science:
- Addiction Medicine
- Behavioral Health
- Pharmacotherapy Adherence
Background:
- Contingency Management (CM) is an effective behavioral intervention for improving health behaviors.
- Adherence to injectable medications for opioid and alcohol use disorders is a significant challenge.
- CM offers a potential solution to enhance treatment adherence for these conditions.
Purpose of the Study:
- To compare medication adherence in veterans receiving injectable treatments with and without Contingency Management.
- To evaluate the impact of CM on adherence rates for XR-naltrexone and XR-buprenorphine.
Main Methods:
- Retrospective cohort study comparing two groups of veterans (n=42 each).
- One group received injectable medication with CM for adherence.
- The other group received injectable medication prior to CM implementation.
Main Results:
- The CM cohort received 1.62 times more medication doses than the comparison group.
- Adjusted analyses showed significantly higher mean doses in the CM cohort (8.59) versus the comparison cohort (5.36; p < .001).
- CM facilitated access to XR-buprenorphine, which was unavailable in the earlier period.
Conclusions:
- Contingency Management is a vital strategy for improving adherence to medications for substance use disorders.
- CM implementation was linked to significantly higher medication adherence rates.
- Adapted CM approaches may reduce administrative burdens while maintaining effectiveness.
Related Concept Videos
01:28Drug Therapy
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
01:01Dosage Regimen: Fixed Dose
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
01:15Drug Dosage Regimen: Overview
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
01:17Drug Dependence
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
01:28Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
01:24Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...